Title: Associate Research Scientist in Surgery Otolaryngology
Company: Yale School of Medicine
Location: New Haven, Connecticut, United States
Dimitra P. Vageli, Associate Research Scientist in Surgery Otolaryngology at Yale School of Medicine, has been recognized by Marquis Who’s Who Top Scientists for dedication, achievements, and leadership in medical research and education.
When Dr. Vageli was five years old, she took an interest in how life starts and how everything happens in the world. Her teacher explained the field of biology, and Dr. Vageli began studying plants and small animals to figure out what happens in their life. She has continued those studies to this day, and is now an associate research scientist in surgical otolaryngology at Yale School of Medicine. She is also a leading member of the neoplasia section of Larynx lab, where she has organized the training of otolaryngology residents and postdoctoral and postgraduate students. Their findings from in-vitro and in-vivo studies, funded by Ohse Research Grants, support the role of gastro-duodenal reflux in hypopharyngeal carcinogenesis, mediated through the NF-kB pathway. Her current research interest includes the mechanism that bile promotes its carcinogenic effect in hypopharynx and the characterization of the tumorigenic potential of other risk factors that may accelerate tumorigenic potential via NF-kB activation in hypopharyngeal mucosa. In the past, she has researched mismatch DNA repair phenotypes in human cancers.
Dr. Vageli prepared for her endeavors by earning a Bachelor of Science in biology from the School of Natural Sciences at the University of Patras in Greece in 1989 and a PhD in molecular oncology and biotechnology from the School of Health Sciences at the University of Crete in Greece in 1998, as well as by completing an internship in clinical microbiology and biochemistry from Army Hospital-NIMTS in Greece. During her time in the PhD program, Dr. Vageli had the opportunity to do some research and decided that she wanted to focus on studies to help humans. Her PhD thesis used a revolutionary molecular biology technique for that time, Polymerase Chain Reaction. This helped to demonstrate that, in bladder cancer, there is often an overexpression of the well-known ras oncogenes family, potentially due to genetic alterations (known as microsatellite instability) in regulating elements of these genes. Dr. Vageli is particularly proud of this achievement, and considers presenting the thesis to an audience of top physicians, surgeons, and biologists to be a professional highlight. After completing her dissertation, she worked for more than 10 years as a principal investigator in pathological studies regarding cancer disease with related publications, mainly concerned with the significance of genetic alterations and changes in the expression of mismatch DNA repair genes. She collaborated with many departments, institutions, and hospitals in Greece, as well as the University of Liverpool in England and Wake Forest University of North Carolina. During that period, she organized and established the first diagnostic and research molecular pathology laboratory in the Medical School of Thessaly, Greece, where she performed in parallel diagnostic and research projects, developing expertise in molecular histopathological methods.
Contact Dr. Vageli